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. 2014 Jan;24(1):125–131. doi: 10.1101/gr.163394.113

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© 2014 Sung et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 5. — Germline transmission and mutant phenotypes of the Prkdc mutant mouse. (A) Detailed genotypes of F₀ mutants (♂ 25 and ♀ 33, upper panel) and determination of genotypes of their F₁ progenies (#1 and #7) by fPCR (lower panel). Note that a mutant allele (+2) of female founder #33 was only detected by fPCR (Supplemental Table 2). Using lymphocytes isolated from peripheral blood (PBMC), lymph node (LN), spleen, and thymus, frequencies of CD4⁺ and CD8⁺ T cells (B) and those of CD3⁺ T cells and CD19⁺ B cells (C) were determined. The abnormal frequencies of immune cells are denoted in red. BALB/c and scid mice, positive and negative controls for B and T lymphocytes, respectively.