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. 2014 Jan;24(1):37–51. doi: 10.1101/gr.161570.113

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© 2014 Renaud et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 6. — The POLR3G gene duplication leads to neo-functionalization of promoter sequences rather than gene product. (A) The POLR3G and POLR3GL promoters are differentially regulated, probably at least in part through exclusive binding of MYC to the POLR3G TSS. (B) Model of POLR3G and POLR3GL regulation. The model assumes a constant cellular level of POLR3GL and a variable level of POLR3G that allows adaptation of total Pol III levels to cell growth and proliferation conditions. If the cell loses POLR3G, the constant expression level of POLR3GL allows survival. If the cell loses POLR3GL, it can encounter conditions when POLR3G expression levels are too low for survival.