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. 2014 Jan;24(1):52–63. doi: 10.1101/gr.156141.113

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© 2014 Gregory and Cheung; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 2. — Cis-regulation of KDM4C. (A) KDM4C expression levels in cultured B cells of 24 unrelated individuals (open circles) and primary B cells of nine unrelated individuals (filled circles) are shown relative to the individual with the lowest expression, as measured by qRT-PCR. (B) Western blot analysis of KDM4C protein expression with cultured B cells from three individuals with the lowest and three individuals with the highest KDM4C gene expression (n = 3). (C) Scatter plot of KDM4C gene and protein expression in the cultured B cells from 24 individuals in A; significant correlation in transcript and protein expression was found (R² = 0.39, P < 0.05). (D) KDM4C expression in B cells is shown by their genotype at SNP rs7868863 (P = 0.006, allelic association). The SNP position is indicated.