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. 2013 Oct 24;3:20. doi: 10.1186/2043-9113-3-20

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Copyright © 2013 Di Carlo et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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mTOR signaling pathway (#hsa04150). TOR signaling pathway (#hsa04150) including the identified PPL (3/31/09 release). (1) The pathway host-gene (RSK) expresses a protective intragenic miRNA (miR-1976) which (2) acts against the expression of the MLL transcription factor. (3) MLL is responsible for HOXA9 transcription, that (4) leads to the expression of miR-196b which, if expressed, (5) would target RICTOR, dysregulating the mTORC2 complex in which RICTOR plays a central role.