Table 3.
8-OHdG alteration associated with overall survival of serous ovarian cancer patients (N = 72)
|
Characteristic |
Univariate analysis |
p value |
Multivariate analysis |
p value |
||
|---|---|---|---|---|---|---|
| HR | 95 % CI | HR | 95 % CI | |||
| FIGO stage |
|
|
|
|||
| I |
1.00 |
Reference |
|
1.00 |
Reference |
|
| II |
1.42 |
0.68-6.25 |
|
1.21 |
0.43-8.02 |
|
| III |
6.78 |
1.66-18.41 |
|
2.25 |
1.24-6.08 |
|
| IV |
9.43 |
3.61-27.87 |
<0.01 |
3.28 |
1.47-9.54 |
<0.01 |
| Grade |
4.12 |
1.35-12.69 |
<0.01 |
2.57 |
1.62-3.45 |
<0.01 |
| Suboptimal CRS |
2.16 |
1.25-3.85 |
<0.01 |
1.65 |
1.19-2.55 |
0.02 |
| Ascites |
1.47 |
1.26-3.04 |
0.01 |
1.23 |
1.08-2.36 |
0.04 |
| Nadir CA-125 level |
1.02 |
1.01-1.04 |
<0.01 |
1.01 |
1.00-1.03 |
<0.01 |
| p53 positive |
1.30 |
1.09-4.39 |
0.02 |
1.13 |
0.96-2.41 |
0.10 |
| 8-OHdG (T/A) |
1.35 |
1.13-3.42 |
<0.01 |
1.18 |
1.01-2.07 |
<0.01 |
| hOGG1 protein (T/A) |
0.84 |
0.78-1.06 |
0.54 |
0.89 |
0. 88–1.02 |
0.65 |
| Age | 1.01 | 1.00-1.01 | 0.04 | 1.00 | 0.98-1.01 | 0.21 |
HR, Hazard ratio; CI, Confidence interval; CRS, Cytoreductive surgery. T/A, Tumor/Adjacent non-tumor tissue.