TABLE 2.
Mean synonymous and nonsynonymous substitution rates in conserved and hypervariable regions of Ad7 and Ad4
| Serotype | Mean substitution ratea ± SD
|
|||
|---|---|---|---|---|
| Conserved regions
|
Hypervariable regions
|
|||
| Synonymous | Nonsynonymous | Synonymous | Nonsynonymous | |
| Ad7 | 39.9 ± 6.4 | 1.7 ± 0.6* | 20.6 ± 8.8 | 28.9 ± 5.6 |
| Ad4 | 17.6 ± 3.6 | 1.2 ± 0.4* | 4.0 ± 2.5 | 8.7 ± 2.3 |
a
Rates were determined through pairwise sequence comparison and are expressed as synonymous substitutions per 1,000 synonymous sites and nonsynonymous substitutions per 1,000 nonsynonymous sites. *, significant differences between synonymous and nonsynonymous substitution rates.