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1,25(OH)2D/VDR regulation of DNA damage repair (DDR) in keratinocytes. UVB causes DNA damage in the form of cyclobutane pyrimidine dimers (CPD) and pyrimidine(6,4)pyrimidone photoproducts (6,4PP). If these DNA lesions are not repaired mutations leading to cancer will result. This is the job of DDR, a multienzyme pathway regulated by VDR and 1,25(OH)2D.
