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. 2013 Nov 8;5(4):1469–1484. doi: 10.3390/cancers5041469

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Regulation of cholesterol metabolism in gliomas. Cholesterol homeostasis is regulated by uptake, synthesis and efflux. EGFR/PI3K/Akt signaling upregulates LDLR expression mediated by SREBP-1 to promote cholesterol uptake. Activation of LXR stimulates ABCA1 expression and promotes cholesterol efflux, but also reduces LDLR levels via upregulation of Inducible Degrader of LDLR (Idol), a ubiquitin ligase E3. LXR, liver X receptor; ABCA1, ATP-binding cassette transporter member 1; LDL, low density lipoprotein; LDLR, LDL receptor.