CPE and CFSE regulate lipid levels. (A) serum total cholesterol; (B) liver total cholesterol; (C) serum triglyceride; (D) liver triglyceride; (E) serum LDL cholesterol and (F) serum HDL-cholesterol; (G–I) H and E staining (×400) of livers from the (G) chow diet, (H) HF, (I) HF + CPE and (J) HF + CFSE mice; (K–N) Oil red O staining (×400) of the livers from the (K) chow diet, (L) HF, (M) HF + CPE and (N) HF + CFSE mice. The values shown are means ± SE (n = 6). a,b,c,abmean values with different letters were significantly different (p < 0.05). HF: high-fat diet; HF + CPE: high-fat diet supplemented with citrange peel extract; HF + CFSE: high-fat diet supplemented with citrange fruit and seed extract.