Table 3.

Tandem Aldol-Michael reactions of barbituric acid 1b with aldehydes in aqueous diethylamine medium ^a.

Entry	4	R	Yield (%) b
1	4a	Ph	98
2	4b	p-CH3Ph	95
3	4c	p-ClPh	95
4	4d	p-CH3OPh	91
5	4e	2-Naphthaldehyde	93

^aAll reactions were carried out with barbituric acid 1b (3 mmol), aldehydes 2 (1.5mmol) and amine (1.5mmol) in water (1.5 mL) for the specified time;

^bYield of isolated product.