TABLE 3.
Predictors of resistance to fluconazole among all patients with candidemiaa
| Type of analysis and variable | No. (%) of patients with isolates that were:
|
Odds ratio | 95% Confidence interval | P | |
|---|---|---|---|---|---|
| Resistantb | Susceptiblec | ||||
| Univariable | |||||
| Black race | 21 (60) | 349 (39) | 2.29 | 1.18-4.45 | 0.01 |
| Neutropeniad | 8 (24) | 93 (11) | 2.36 | 1.10-5.07 | 0.03 |
| Transplant recipient | 5 (15) | 46 (5) | 2.9 | 1.18-7.23 | 0.02 |
| HIV infected | 9 (26) | 57 (6) | 4.6 | 2.25-9.50 | <0.0001 |
| Required hospital admission in prior 3 mo | 28 (82) | 506 (58) | 3.2 | 1.34-7.65 | 0.005 |
| Received systemic azoles in prior 3 mo | 8 (23) | 108 (12) | 2.1 | 1.0-4.5 | 0.05 |
| Outpatient acquirede | 16 (46) | 261 (29) | 2.0 | 1.0-3.8 | 0.03 |
| Multivariable | |||||
| Transplant recipient | 4.2 | 1.5-11.7 | 0.007 | ||
| HIV infected | 5.2 | 2.2-12.5 | 0.0002 | ||
| Required hospital admission in prior 3 mo | 2.9 | 1.2-7.1 | 0.02 | ||
a
Antifungal susceptibility data were available for 935 isolates (35 resistant and 900 susceptible).
b
MIC, ≥ 64 μg/ml.
c
MIC, < 8 μg/ml.
d
Presence of neutropenia at the time of candidemia diagnosis.
e
Positive blood culture either prior to or on the day of hospital admission.