TABLE 1.

Results of typing of 188 H. influenzae strains isolated from 30 patients with CF at three different hospitals in Spain^a

Patient no.	Sexb	Patient age at isolate collection (yr/mo)	Sampling period (mo)	No. of H. influenzae strainsc	PFGE pattern(s)d	Strain distribution according to PFGE pattern(s)	Persistence of PFGE pattern (mo)	OMP variant(s)	Biotype(s) (no. of strains)
1	M	37/10	80	15	1A, 1B, 2	10, 4, 1	80, 15, 0	1Aa, 1Ab, 1Ac	VI (6)-VIII (2)-VII (2) VI, VI
2	F	18/11	39	3	3, 4	2, 1	39, 0		VII, V
3	F	12/4	41	18	5, 6, 7, 8	14, 2, 1, 1	26, 10, 0, 0	5a(5), 5b, 5c(4), 6a	V, III, II, III
4	M	4/3	58	7	9, 10, 11, 12, 13	1, 2, 1, 1, 2	0, 3, 0, 0, 2		II, I, I, II, I
5	M	15/9	60	3	14, 15	2, 1	1, 0		II, III
6	F	3/10	61	15	16, NT, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26	2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 3	3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 8		II, VII, II, I, IV, III, II, III, I, III, III, I
7	F	4/11	77	15	27, 28, 19, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38	2, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1	<1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0	19a	I, I, II, II, V, III, III, II, II, III, II, II, II
8	M	11/2	41	3	39, 40, 41	1, 1, 1			II, II, II
9	M	21/5	12	3	41, 42, 43	1, 1, 1			III, III, II
10	F	16/8	49	2	44, 45	1, 1			I, II
11	M	11/9	48	3	46, 47, 48	1, 1, 1			II, II, I
12	M	1/6	37	6	49, 41a, 50, 51, 52, 53	1, 1, 1, 1, 1, 1		41a	VIII, II, VII, III, II, II
13	M	5/9	51	5	52a, 54, 55, 56	1, 2, 1, 1	0, 1, 0, 0	52a	II, III, II, II
14	F	8/11	33	1	39	1			II
15	M	18/1	50	1	57	1			I
16	F	6/7	41	1	52	1			VIII
17	F	5/10	48	7	58, 59, 60, 61, 62	2, 1, 1, 1, 2	9, 0, 0, 0, 6		II, V, I, III, II
18	M	4/10	40	4	63, 64, NT, 65	1, 1, 1, 1			I, II, III, I
19	M	22/6	28	2	66, 67	1, 1			IV, III
20	F	3/8	38	9	68, 69, 70, 71, 72, 73	1, 2, 2, 1, 2, 1	0, 11, 1, 0, 2, 0	72a	III, II, I, V, III, II
21	M	1/2	47	7	74, 75, 76, 77, 78, 79, 70	1, 1, 1, 1, 1, 1, 1			I, III, V, III, II, II, I
22	F	5/8	16	5	80, 81, 82, 83	1, 1, 1, 2	0, 0, 0, 2	83a	II, II, II, VII, II
23	M	2/3	40	7	84, 85, 86, 87, 88, 89	1, 2, 1, 1, 1, 1	0, 2, 0, 0, 0, 0		III, II, III, II, II, I
24	M	20/2	19	2	90, 91	1, 1			III, III
25	M	3	17	2	92, 93	1, 1			II, III
26	M	9/7	23	3	94, 95, 96	1, 1, 1			II, II, II
27	M	5/6	14	5	NT, 97, 98, 99, 100	1, 1, 1, 1, 1			III, V, II, II, III
28	M	20/9	72	27	101, 102, 103, 104, 105	23, 1, 1, 1, 1	72, 0, 0, 0, 0	101a	I (20)-II (2)-IV (1), I, I, I, II
29	M	2/5	25	3	106, 107, 108	1, 1, 1			VII, VI, I
30	M	6/5	20	4	109, 110, 111	2, 1, 1	11, 0, 0		I, I, I

^a1A and 1B represent clone 1 subtypes. Lower case letters represent OMP variants. Boldface type represents cross-colonizing strains.

^bM, male; F, female.

^cTotal number of isolates.

^dNT, nontypeable.