TABLE 1.
Number of Pediatric Trials and Participants and Pediatric Burden of Disease by Country Income Level
| All Trials (N = 5373) | RCTs (n = 3771) | Drug RCTs (n = 1526) | Randomized Participants (n = 1 466 689) | Burden of Disease in DALYs | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | %a,b | n | % | |
| High-income countries | 4261 | 79 | 2882 | 76 | 1176 | 77 | 889 448 | 61 | 13 569 772 | 2 |
| Middle-income countries | 746 | 14 | 568 | 15 | 225 | 15 | 260 879 | 18 | 147 338 773 | 25 |
| Low-income countries | 366 | 7 | 321 | 8 | 125 | 8 | 316 362 | 21 | 439 382 261 | 73 |
a
Excluding subjects enrolled in trials with cluster randomization.
b
Enrollment figures missing for 5 trials: 1 in middle-income level and 2 each in high- and low-income levels.