TABLE 2.
Number of Pediatric Trials and Participants and Pediatric Global Burden of Disease According to Condition
| Condition | All Trials, n (N = 4619) | RCTs, n (N = 3246) | Drug RCTs, n (N = 1369) | Randomized Participants, na,b (N = 1 342 049) | Global Burden of Disease in DALYs (Rank) |
|---|---|---|---|---|---|
| Neuropsychiatric conditions | 874 | 642 | 267 | 103 134 | 48 940 526 (5) |
| Nonrespiratory infections and parasitic diseases | 847 | 637 | 188 | 636 471 | 182 759 532 (1) |
| Perinatal conditions | 523 | 430 | 152 | 179 933 | 126 420 651 (2) |
| Malignant neoplasms | 473 | 123 | 77 | 65 199 | 4 110 685 (14) |
| Respiratory diseases | 366 | 290 | 186 | 70 856 | 10 691 264 (8) |
| Respiratory infections | 247 | 211 | 82 | 127 579 | 77 264 822 (3) |
| Digestive diseases | 208 | 137 | 74 | 16 757 | 7 695 304 (9) |
| Diabetes mellitus | 138 | 117 | 49 | 14 935 | 542 738 (20) |
| Congenital anomalies | 129 | 89 | 53 | 10 406 | 24 256 090 (7) |
| Musculoskeletal diseases | 128 | 86 | 38 | 11 189 | 2 489 737 (17) |
| Nutritional deficiencies | 106 | 93 | 14 | 42 306 | 27 844 589 (6) |
| Unintentional injuries | 101 | 76 | 26 | 10 064 | 52 837 234 (4) |
| Cardiovascular diseases | 96 | 67 | 32 | 13 497 | 6 683 866 (11) |
| Genitourinary diseases | 96 | 62 | 43 | 6751 | 1 888 187 (18) |
| Sense organ diseases | 77 | 50 | 20 | 7500 | 6 024 722 (12) |
| Skin diseases | 67 | 42 | 29 | 3531 | 1 064 523 (19) |
| Oral conditions | 63 | 55 | 16 | 12 062 | 2 532 862 (16) |
| Endocrine disorders | 62 | 29 | 22 | 3654 | 3 682 728 (15) |
| Nonmalignant neoplasms | 9 | 3 | 1 | 422 | 372 642 (21) |
| Intentional injuries | 5 | 5 | 0 | 5479 | 7 130 242 (10) |
| Maternal conditions | 4 | 2 | 0 | 324 | 5 270 155 (13) |
a
Excluding subjects enrolled in trials with cluster randomization.
b
Enrollment figures missing for 5 trials: 1 each in infectious diseases, perinatal conditions, nutritional deficiencies, childhood cluster diseases, and sense organ diseases.