Table 1.
Functional categorization of the top 50 core genes with the highest relative rates of nonsynonymous substitution (with automated or manual annotation)
| Class | No. of genes | Examples of genes and functional roles |
| Redox | 18 | Nitrous oxide reductase (nosY) |
| Regulation of denitrification (nirQ) | ||
| Ethanol oxidation (erbR, eraS) | ||
| Glutathione S-transferases | ||
| Epoxide hydrolase | ||
| Oxidases | ||
| Dehydrogenases | ||
| Oxidoreductase | ||
| Dioxygenase | ||
| Transport | 7 | MFS transporters |
| ABC transporters | ||
| Multidrug efflux protein (norA) | ||
| Secretion | 5 | Type III secretion system (pscQ) |
| Phospholipases | ||
| Exotoxin (exoY) | ||
| Regulatory | 7 | Two-component response regulators |
| Transcriptional regulators | ||
| RNA polymerase sigma-70 factor | ||
| Hydrolysis | 8 | Beta-lactamases |
| Hydrolases | ||
| Miscellaneous | 5 | Kinases |
| Transferases |