Figure 10.
Clinical trial result for subject 8: PZMPC (blue) versus invariant-zone-MPC (red). There are no results for the nighttime-basal control strategy. Continuous glucose monitor, solid line; YSI, filled circles; finger stick, filled squares. Filled diamonds at the top of the yBG plot indicate a hypoglycemia alarm with 16 gCHO treatment. Filled circles at the bottom of the yBG plot indicate meals. The green dashed line depicts the basal profile during the PZMPC trial. The basal profile during the invariant-zone-MPC trial was slightly different and not plotted. The PZMPC strategy performs a 1 h 21 min (21:21–22:42) pump suspension at the end of daytime, starting shortly before the transition to the nighttime zone. This suspension is in response to overdelivery after dinner. The PZMPC strategy further performs a 40 min (00:16–00:56) pump suspension in response to a sudden drop in blood glucose value. Note that the blood glucose level during the drop is within the daytime zone 80–140 mg/dl. With PZMPC, the blood glucose level is allowed to rise during the night. In contrast, the invariant-zone-MPC strategy performs corrective action in the period 4:00 am–5:00 am.