Figure 11.
Clinical trial result for subject 10: PZMPC (blue) versus invariant-zone-MPC (red). There are no results for the nighttime-basal control strategy. Continuous glucose monitor, solid line; YSI, filled circles; finger stick, filled squares. Filled diamonds at the top of the yBG plot indicate a hypoglycemia alarm with 16 gCHO treatment. Filled circles at the bottom of the yBG plot indicate meals. The green dashed line depicts the basal profile during the PZMPC trial. The basal profile during the invariant-zone-MPC trial was slightly different and not plotted. The PZMPC strategy performs a 2 h (21:45–23:45) pump suspension, starting at the start of the transition from the daytime zone to the nighttime zone, and permits the blood glucose level to rise steadily. The invariant-zone-MPC strategy also performs a prolonged pump suspension in the late evening (20:46–23:17, except one controller step at 22:21) but as a result of overdelivery after dinner. The invariant-zone-MPC strategy furthermore administers insulin exceeding the basal rate around 1:00 AM, whereas the PZMPC strategy administers only the basal rate at comparable blood glucose levels during nighttime.