Figure 12.
Clinical trial result for subject 11: PZMPC (blue) versus invariant-zone-MPC (red). There are no results for the nighttime-basal control strategy. Continuous glucose monitor, solid line; YSI, filled circles; finger stick, filled squares. Filled diamonds at the top of the yBG plot indicate a hypoglycemia alarm with 16 gCHO treatment. Filled circles at the bottom of the yBG plot indicate meals. The green dashed line depicts the basal profile during the PZMPC trial. The basal profile during the invariant-zone-MPC trial was slightly different and not plotted. The PZMPC strategy performs a 2 h 45 min (22:01–00:46) pump suspension from the start of the transition from the daytime zone to the nighttime zone and allows the blood glucose level to rise steadily throughout the night. Note, however, that the blood glucose trajectory for the PZMPC case is beneath the daytime zone during the period (22:58–00:32), and thus the invariant-zone-MPC strategy would be expected to perform an extended pump suspension in that case also.