Skip to main content
. 2013 Nov 1;7(6):1538–1546. doi: 10.1177/193229681300700614

Figure 5.

Figure 5.

Hypothetical model of IL-1 and IL-1Ra tissue and sensor interactions at sites of glucose sensor implantation in normal tissue. Hypothetical model of role of IL-1(IL-1a and IL-1B) and IL-1Ra at sensor implantation sites of glucose sensors. This hypothetical model outlines the various possible IL-1-related pathways /interactions that are involved in controlling tissue reactions at sites of glucose sensor–tissue reactions as well as glucose sensor function in vivo. M1, (proinfammatory) macrophage subpopulations, red cells; M2, (anti-infammatory) macrophage subpopulations, green cells; red triangles, IL-1 (IL-1a and IL-1B); green triangles, IL-1Ra; red stars, IL-1-induced proinflammatory and profbrotic factors; green circles and ovals, IL-1Ra-induced/related anti-inflammatory and antifibrosis factors; VPF, vasopermeability factors; LCF leukocyte chemotactic factors.