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. 2004 Apr;3(2):339–347. doi: 10.1128/EC.3.2.339-347.2004

FIG. 8.

FIG. 8.

Localized sequence similarities among Hap4 homologs in yeasts. Selected portions of amino acid sequences of Hap4 homologs from S. cerevisiae (Scer), S. bayanus (Sbay), S. mikatae (Smik), S. paradoxus (Spar), S. castellii (Scas), S. kluyveri (Sklu), and K. lactis (Klac) were aligned based in part on an alignment displayed at the SGD website (http://db.yeastgenome.org/cgi-bin/FUNGI/nph-showAlign?locus = YKL109W). Numbers refer to amino acid residues; no number is assigned for the homolog from S. kluyveri because this open reading frame has not been rigorously defined. (A) Similarity in a domain of Hap4 that interacts with the Hap2, Hap3, and Hap5 DNA-binding protein complex. (B) Similarity in the region defined in this report as the N-terminal activation domain. Bold underlined letters represent residues which, when mutated, affected the activity of LexA-Hap4(124-329). (C) Similarity in the region defined in this report as the C-terminal activation domain. Bold underlined letters represent residues which, when mutated, affected the activity of LexA-Hap4(359-476).