Table 1. Summary of mutations that alter STAT2 signaling and function.

Phenotype	STAT2 mutation	Domain	References
Prolonged Y690 phosphorylation	S287A	CCD	34
	Y631F	SH2	35
Reduced or no Y690 phosphorylation	S287D	CCD	34
	R601L	SH2	6
	P630L	SH2	36
	Y690F	C-terminus of SH2 domain	28
	R694N	C-terminus of SH2 domain	6
Reduced or no nuclear translocation	R374A + K375A	DBD	37
	R409A + K415A	DBD	37
Reduced or no nuclear export	L737A + L741A	TAD	38
	L740A + L741A	TAD	39
	L745A	TAD	39
	L751A	TAD	39
Reduced DNA-binding	V453I + V454I	DBD	40
Reduced transcriptional activity	K390R	DBD	41
Abolished STAT4 activation	Y833F	TAD	42