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. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: J Am Chem Soc. 2013 Nov 4;135(45):10.1021/ja408073m. doi: 10.1021/ja408073m

Scheme 5.

Scheme 5

The relationship between the barrier ΔE‡, the deformation energy of reactants ΔEdef, and their interaction energy, ΔEint, at the TS: (a) ΔEint < 0, and (b) ΔEint > 0.