Table 5.
Presentation of different parameters interfering with Ibuprofen permeation through rat skin for traditional formulations (mean ± SD, n = 3).
| Formulation | Jss (μg/cm2.h) | P (cm/h) | D (appearance) (cm2/h) | Tlag (h) | Full-factorial state |
|---|---|---|---|---|---|
| Control | 83.5 ± 6.3 | 128 | 0.0069 ± 0.0008 | 2.6 ± 0.17 | - |
| 1 | 137 ± 7.9 | 2.75 ± 0.29 | 0.012 ± 0.005 | 1.86 ± 0.12 | +++ |
| 2 | 133 ± 9.4 | 2.66 ± 0.31 | 0.01 ± 0.007 | 1.97 ± 0.14 | ++- |
| 3 | 120 ± 4.5 | 2.4 ± 0.18 | 0.0066 ± 0.0005 | 2.39 ± 0.25 | +-- |
| 4 | 123 ± 6.2 | 2.46 ± 0.21 | 0.0097 ± 0.0008 | 2.27 ± 0.18 | +-+ |
| 5 | 118 ± 7.7 | 2.36 ± 0.17 | 0.0076 ± 0.0004 | 2.32 ± 0.15 | -++ |
| 6 | 112 ± 5.1 | 2.24 ± 0.12 | 0.0097 ± 0.0006 | 2.44 ± 0.1 | --+ |
| 7 | 115 ± 3.9 | 2.3 ± 0.21 | 0.011 ± 0.0003 | 2.35 ± 0.19 | -+- |
| 8 | 107 ± 4.3 | 2.14 ± 0.16 | 0.0064 ± 0.0006 | 2.4 ± 0.19 | --- |