Table 6.
Presentation of different parameters interfering with Ibuprofen permeation through rat skin for novel formulations (mean ± SD, n = 3)
| Full-factorial state | Tlag (h) | D (appearance) (cm 2 /h) | P (cm 2 /h) | Jss (μg/cm 2 .h) | Formulation |
|---|---|---|---|---|---|
| - | 2.76 ± 0.185 | 0.0075 ± 0.0007 | 135 ± 6 7.5 | 78.3 ± 6.54 | Control |
| +++ | 1.35 ± 0.14 | 0.0123 ± 0.001 | 3.02 ± 0.27 | 151 ± 12.8 | 1 |
| ++- | 1.27 ± 0.09 | 0.015 ± 0.0009 | 3.38 ± 0.2 | 169 ± 10.3 | 2 |
| +-- | 1.33 ± 0.12 | 0.012 ± 0.0013 | 2.95 ± 0.28 | 147 ± 14.5 | 3 |
| +-+ | 1.66 ± 0.11 | 0.0101 ± 0.0008 | 2.85 ± 0.17 | 144 ± 7.6 | 4 |
| -++ | 0.97 ± 0.066 | 0.025 ± 0.0017 | 3.5 ± 0.33 | 175 ± 15.8 | 5 |
| -++ | 1.18 ± 0.006 | 0.017 ± 0.001 | 3.4 ± 0.36 | 170 ± 18.11 | 6 |
| -+- | 1.05 ± 0.008 | 0.0186 ± 0.0015 | 3.9 ± 0.33 | 195 ± 16.6 | 7 |
| --- | 1.2 ± 0.075 | 0.02 ± 0.0016 | 3.65 ± 0.35 | 180 ± 16.1 | 8 |