Table 6.
Relative risks of all-cause mortality (excluding suicide) and cardiac mortality for current users of various types of antipsychotics versus nonuser psychiatric controls stratified by duration of treatment.
| Outcome |
Exposure type of current users | Duration of treatment | Outcome events | Person-time (Years) | Incidence rate per 1000 PY (95% CI) |
Fully adjusted RR (aRR) (95% CI) |
|---|---|---|---|---|---|---|
| All-cause mortality | Nonuser psychiatric | NA | 7765 | 307,276 | 25.3 (24.7–25.8) | Reference |
| Atypical or typical | <1 year | 16,571 | 176,402 | 93.9 (92.5–95.4) | 1.95 (1.83–2.08)‡ | |
| 1–3 years | 4861 | 56,041 | 86.7 (84.3–89.2) | 1.53 (1.43–1.64)‡ | ||
| >3 years | 2409 | 44,449 | 54.2 (52.1–56.4) | 1.20 (1.11–1.29)‡ | ||
| Atypical | <1 year | 4333 | 49,387 | 87.7 (85.1–90.4) | 1.68 (1.55–1.82)‡ | |
| 1–3 years | 2068 | 26407 | 78.3 (75.0–81.8) | 1.42 (1.31–1.55)‡ | ||
| >3 years | 955 | 18,318 | 52.1 (48.9–55.6) | 1.15 (1.04–1.27)‡ | ||
| Typical | <1 year | 11,989 | 124,518 | 96.3 (94.6–98.0) | 1.98 (1.84–2.13)‡ | |
| 1–3 years | 2430 | 24,906 | 97.6 (93.7–101.5) | 1.56 (1.43–1.69)‡ | ||
| >3 years | 1054 | 17,581 | 60.0 (56.4–63.7) | 1.17 (1.06–1.28)‡ | ||
| Olanzapine | <1 year | 659 | 18,111 | 36.4 (33.7–39.3) | 1.21 (1.06–1.38)‡ | |
| 1–3 years | 395 | 9674 | 40.8 (36.9–45.1) | 1.04 (0.91–1.20) | ||
| >3 years | 251 | 7200 | 34.9 (30.7–39.5) | 0.78 (0.67–0.91)‡ | ||
|
| ||||||
| Cardiac mortality | Nonuser psychiatric | NA | 1289 | 200,988 | 6.4 (6.1–6.8) | Reference |
| Atypical or typical | <1 year | 1707 | 95,129 | 17.9 (17.1–18.8) | 1.85 (1.53–2.24)‡ | |
| 1–3 years | 563 | 32,383 | 17.4 (16.0–18.9) | 1.60 (1.30–1.95)‡ | ||
| >3 years | 208 | 18,131 | 11.5 (10.0–13.1) | 1.31 (1.04–1.65)† | ||
| Atypical | <1 year | 761 | 42,705 | 17.8 (16.6–19.1) | 1.51 (1.38–1.66)‡ | |
| 1–3 years | 315 | 20,399 | 15.4 (13.8–17.2) | 1.26 (1.11–1.43)‡ | ||
| >3 years | 124 | 10,180 | 12.2 (10.1–14.5) | 1.16 (0.97–1.41) | ||
| Typical | <1 year | 918 | 50,850 | 18.1 (16.9–19.3) | 1.92 (1.51–2.45)‡ | |
| 1–3 years | 204 | 9216 | 22.1 (19.2–25.4) | 1.75 (1.34–2.28)‡ | ||
| >3 years | 58 | 4848 | 12.0 (9.1–15.5) | 1.21 (0.86–1.71) | ||
| Olanzapine | <1 year | 111 | 15,615 | 7.1 (5.9–8.6) | 1.67 (1.18–2.35)‡ | |
| 1–3 years | 65 | 7269 | 8.9 (6.9–11.4) | 1.57 (1.09–2.26)† | ||
| >3 years | 30 | 3881 | 7.7 (5.2–11.0) | 1.24 (0.79–1.94) | ||
*P < 0.10, † P < 0.05, ‡ P < 0.01.
Abbreviations: aRR: adjusted relative risk; CI: confidence interval; NC: not calculable; PY: person-years.