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. 2013 Dec 31;7:215. doi: 10.3389/fnbeh.2013.00215

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Copyright © 2013 Spinelli, Müller, Friedel, Sigrist, Lesch, Henkelman, Rudin, Seifritz and Pryce.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The time line of the study. Animals were weaned at postnatal week 4 and assigned to experiment 1 or 2. All mice were exposed to the adolescence stress procedure and context re-exposure. Mice in experiment 1 were subsequently tested during late adolescence in the novelty-induced hypophagia (NIH) and elevated plus maze (EPM) tests. In adulthood, a serial blood sampling (SBS) procedure was conducted, afterwards animals were trained and tested in the probabilistic reversal learning (PRL) task. Mice in experiment 2 were tested during late adolescence in the open field (OF), and perfused in adulthood to collect the brains for structural magnetic resonance imaging.