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Boldine decreases markers of kidney damage in diabetic rats. Panels show immunohistochemistry for collagen III (a) and α-smooth muscle actin (SMA) (b). Top panels show fields of kidney sections from control (C) rats. Central panels show fields of kidney sections from diabetic rats (D) and the bottom panels are from diabetic rats treated with 50 mg/Kg/day boldine (DB). Each picture is representative of at least 5 different animals. Arrowheads show staining in vascular tissue.
