Table 1.
Pathophysiological status of experimental animals.
| Control (C) | Diabetic (D) | Control boldine (CB) | Diabetic boldine (DB) | |
|---|---|---|---|---|
| Glycemia (mg/dL) | 141 ± 8 | 371 ± 74*** | 147 ± 8 | 253 ± 31† |
| Weight (g) | 530 ± 28 | 223 ± 25*** | 458 ± 22 | 235 ± 19*** |
| Urine volume (mL) | 16 ± 2 | 28 ± 5* | 15 ± 3 | 24 ± 3 |
| Plasma osmolality (mOsmol/Kg) | 290 ± 4 | 310 ± 8 | 300 ± 6 | 300 ± 8 |
| Urine omoles (in 24 h) | 17 ± 1 | 23 ± 4 | 15 ± 1 | 24 ± 3 |
| MDA plasma (nM) | 50 ± 6 | 117 ± 9** | 57 ± 7 | 121 ± 22** |
| MDA urine (pmoles in 24 h) | 167 ± 20 | 842 ± 218** | 127 ± 15 | 764 ± 97** |
| Mean blood pressure (mmHg) | 116 ± 5 | 147 ± 12* | 109 ± 9 | 119 ± 5† |
Parameters observed in control (C), diabetic (D), and control or diabetic rats treated with 50 mg/Kg boldine (CB and DB, resp.) measured at the end of the experiment. Values represent the average ± SEM of at least 5 animals per group. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001 compared to control; † P ≤ 0.05 compared to diabetic, using one-way ANOVA followed by Bonferroni's post hoc test.