Table 1.
Odds ratios (OR) and 95% confidence intervals (CI) for risk of non-Hodgkin lymphoma (NHL) and NHL by histologic subtype groups associated with the single nucleotide polymorphism (SNP) at position −1 of the Kozak consensus sequence of CD40 gene (rs1883832, C>T), restricted to HIV-negative non-Hispanic white participants
| NHL | Genotype | Replication set1 | Pooled set2 | ||
|---|---|---|---|---|---|
| Cases/controls | OR3 (95%CI) | Cases/controls | OR3 (95%CI) | ||
| All NHL | CC | 420/661 | 1.0 | 1,343/1,992 | 1.0 |
| CT | 351/460 | 1.2 (1.0–1.5) | 1,041/1,366 | 1.1 (1.0–1.3) | |
| TT | 84/85 | 1.6 (1.2–2.3) | 229/242 | 1.4 (1.2–1.8) | |
| CT/TT | 435/545 | 1.3 (1.1–1.5) | 1,270/1,608 | 1.2 (1.1–1.3) | |
| p trend | 0.001 | 0.00009 | |||
| DLBCL | CC | 125/661 | 1.0 | 391/1,992 | 1.0 |
| CT | 116/460 | 1.3 (1.0–1.8) | 311/1,366 | 1.2 (0.98–1.4) | |
| TT | 31/85 | 2.1 (1.3 –3.3) | 72/242 | 1.6 (1.2–2.1) | |
| CT/TT | 147/545 | 1.4 (1.1–1.9) | 383/1,608 | 1.2 (1.0–1.4) | |
| p trend | 0.001 | 0.002 | |||
| FL | CC | 44/661 | 1.0 | 244/1,992 | 1.0 |
| CT | 43/460 | 1.4 (0.91–2.2) | 213/1,366 | 1.3 (1.1–1.6) | |
| TT | 11/85 | 1.9 (0.96–3.9) | 46/242 | 1.6 (1.1–2.2) | |
| CT/TT | 54/545 | 1.5 (0.99–2.3) | 259/1,608 | 1.3 (1.1–1.6) | |
| p trend | 0.04 | 0.001 | |||
| CLL/SLL | CC | 119/661 | 1.0 | 263/1,992 | 1.0 |
| CT | 87/460 | 1.1 (0.79–1.5) | 202/1,366 | 1.1 (0.92–1.4) | |
| TT | 12/85 | 0.78 (0.41–1.5) | 38/242 | 1.2 (0.81–1.7) | |
| CT/TT | 99/545 | 1.0 (0.76–1.4) | 240/1,608 | 1.1 (0.94–1.4) | |
| p trend | 0.84 | 0.19 | |||
EpiLymph centers except Germany (Spain, France, Italy, Ireland and Czech Republic).
Pooled data include also Germany center of EpiLymph and San Francisco Bay Area NHL1 and NHL2 study data.5
Odds ratios and 95% confidence intervals are adjusted for age (continuous), sex and individual study center.
Abbreviations: DLBCL: diffuse large B-cell lymphoma; FL: follicular lymphoma; CLL/SLL: chronic lymphocytic leukemia/small lymphocytic lymphoma.