TABLE 5.

Effect of ethanol and potential treatment strategies on fatality after administration of 1500 mg/kg GHB i.v.

Ethanol was administered intravenously as a 1.0 or 2.0 g/kg bolus to reach target concentrations of 0.1–0.2% and 0.3–0.4% (w/v), followed by a 1.85 mg/min infusion until 8 hours after GHB administration. GHB administration was given 60 minutes after the ethanol bolus and was considered time 0. l-Lactate (66 mg/kg, followed by an infusion of 302.5 mg/kg per hour for 8 hours) and SCH50911 (5 mg/kg) were administered 5 minutes after GHB. Data are presented as the number of fatalities/total animals evaluated.

Dose Administered	No Treatment	l-Lactate	SCH50911
GHB	0 of 10	——	——
GHB + ethanol 0.1–0.2%	4 of 10	0 of 10	——
GHB + ethanol 0.3–0.4%	9 of 10	5 of 10	0 of 10