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. 2014 Jan;42(1):172–181. doi: 10.1124/dmd.113.053850

Fig. 6.

Fig. 6.

(A) Regulation of DME and transporter gene expression by LTA or LPS in primary hepatocytes from CAR+/+ and CAR−/− mice. Primary hepatocytes from CAR+/+ and CAR−/− mice were treated with (A) saline or LTA (50 ng/ml) for 8 hours, or (B) saline or LPS (1 μg/ml) for 16 hours. RNA was isolated, and real-time PCR was performed, as described earlier. n = 5–6 per group. All data are presented as ±S.D. and standardized for cyclophilin mRNA levels. *Indicates significant difference (P < 0.05) between saline and LTA/LPS of CAR+/+ groups; ‡ indicates significant differences (P < 0.05) between saline samples of CAR+/+ and CAR−/− groups; and # indicates significant difference (P < 0.05) between saline and LTA/LPS of CAR−/− group. The experiments were repeated at least thrice.