Fig. 7.

Proposed role of PDZK1 in selective recruitment of motors to Oatp1a1-associated vesicles. As seen in (A), we propose that one or more of the cytosolic domains of vesicle-associated Oatp1a1 bind a protein complex that contains dynein, independent of the presence of PDZK1. As seen in (B), PDZK1 bound to the C-terminal PDZ binding consensus sequence (KTKL) of vesicle-associated Oatp1a1 recruits a complex of proteins that includes kinesin-1 (Kif5B). In this situation, activity of these motors is coordinately regulated, such that inhibition of one type of motor will affect activity of the other. KO, knockout; WT, wild-type.