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Potential Mechanisms Underlying APOL1-Associated Nephropathy
| Potential Mechanism | Primary Site (Effect) | Additional Sites |
|---|---|---|
| Expression in the kidney | Podocyte (? autophagy) | Glomerular endothelium and tubules |
| Expression in small arterioles | Media | Intima |
| Altered circulating ApoL1 protein |
Glomerular filtration, subsequent proximal tubule reabsorption |
Direct effects on glomerular endothelium |
| Altered HDL cholesterol | Effects on glomerular and vascular endothelium | — |
