Fig. 7.

VU0403602 and M1 (VU0453103) induce epileptiform activity in CA3 neurons in hippocampus. Amplitude and interevent interval of spontaneous firing were determined using field potential recordings in CA3 in the hippocampal formation. (A) Application of 50 µM DHPG (n = 11), 10 µM VU0403602 (n = 8), or 10 µM M1 (n = 7) for 10 minutes resulted in a robust decrease in the interevent interval of spontaneous events while having no significant effect on amplitude of spontaneous events. Data represent mean ± S.E.M. (B) Sample traces from individual experiments taken before and after the addition of the compound.