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The mGlu5 ago-PAM metabolite M1 induces dose- and time-dependent increases in behavioral adverse effects in male Sprague-Dawley rats receiving a single administration (i.p., 30 mg/kg, n = 2), whereas the inactive metabolite M2 is devoid of AEs (i.p., 30 mg/kg, n = 2). Data represent mean ± S.E.M.
