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Bupropion and its major metabolites after incubation of human liver microsomes with NADPH and G6P. HLMs(f.c. 0.2 mg/ml) were incubated for 1 hour at 37°C in the presence of 1 µM bupropion, 1 mM NADPH, and 1 mM G6P. Data represent mean ± S.D. from at least three independent experiments with pooled microsomes. EHB, erythrohydrobupropion; HB, hydroxybupropion; THB, threohydrobupropion.
