. 2013 Sep;84(3):314–324. doi: 10.1124/mol.113.086595

TABLE 2.

Examples of active compounds for FPR1 and FPR2

	FPR1			FPR2
Compound No.	Binding K_i	Agonist EC₅₀	Antagonist IC₅₀	Binding K_i	Agonist EC₅₀	Antagonist IC₅₀
	nM
Pyrrolidine bis-diketopiperazine scaffold
a: 1754-113	3	^a	1,070	^b	^a	^c
b: 1754-56	2	^a	139	1,320	1,300	NA
c: 1754-26	46	^a	2,680	70	^a	3,480
d: 1754-20	^b	^a	^c	15	^a	452
e: 1754-19	3,370	^a	^c	6	^a	1,410
f: 1754-31	^b	^a	^c	1	^a	81
g: 1754-49	2,320	^a	^c	33	144	NA
Polyphenylurea scaffold
h: 1753-103	4	131	NA	^b	^a	^c

NA, not applicable.

^{^a}

No agonistic activity at up to 12 µM.

^{^b}

K_i greater than 10,000 nM.

^{^c}

No antagonistic activity at up to 10 µM.