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. 2013 Sep;84(3):361–371. doi: 10.1124/mol.113.086967

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Fig. 1. — Nelfinavir and ritonavir modulate MRP4 ATPase activity. (A) The beryllium fluoride (BeFx)–sensitive ATPase activity of ABCC4/MRP4 was determined using the P_i release assay in the presence of various concentrations of NFV, ritonavir (RTV), amprenavir (APV), saquinavir (SQV), or indinavir (IDV). PGE₂, a known MRP4 substrate (Reid et al., 2003) that stimulates ATPase activity (Sauna et al., 2004), was used as a positive control. (B) The effect of indicated compounds on PGE₂-stimulated ATPase activity (left) and quercetin (QCE)-stimulated ATPase activity (right) was evaluated.