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Among common HIV PIs, only NFV is an inhibitor. (A) Immunoblot analysis of MRP4, P-glycoprotein (P-gp), or ABCG2 expression in either HEK293 or Saos2 cells programmed with either empty vector of an MRP4 expression vector. (B) Bis(POM)-PMEA uptake by Saos2 or HEK293 cells containing either empty vector or an MRP4 expression vector was determined in the presence of the indicated PIs.
