Fig. 5.

A pharmacophore model of MRP4 reveals distinct substrate properties. (A) PI MRP4 substrate common features pharmacophore showing nelfinavir mapped. Features include hydrogen bond acceptors (green) with vectors, hydrogen bond donor (purple), and vectors and hydrophobic features (cyan). (B) Mapping PGE₂ (left) and quercetin (middle) onto the common pharmacophore with NFV shown in yellow. (Right) NFV (yellow), PGE₂ (red), and quercetin (gray) are mapped to show that quercetin does not overlap with other two compounds.