Table 2.
Frequencies of CYP2B6, CYP2C19, and ABCB1 polymorphisms in responders and nonresponders to treatment (n = 176)a.
| Genotype | Responders (n = 61) |
Nonresponders (n = 115) |
P value |
|---|---|---|---|
| CYP2B6 | |||
| A785G (*4) | |||
| A/A | 29 (47.5) | 72 (62.6) | 0.15 |
| A/G | 26 (42.6) | 35 (30.4) | |
| G/G | 6 (9.9) | 8 (7.0) | |
| G516T (*9) | |||
| G/G | 38 (62.3) | 86 (74.8) | 0.10 |
| G/T | 19 (31.1) | 27 (23.5) | |
| T/T | 4 (6.6) | 2 (1.7) | |
|
| |||
| CYP2C19 | |||
| G651A (*2) | |||
| G/G | 27 (44.3) | 63 (54.8) | 0.21 |
| G/A | 32 (52.5) | 45 (39.1) | |
| A/A | 2 (3.2) | 7 (6.1) | |
| G636A (*3) | |||
| G/G | 53 (86.9) | 105 (91.3) | 0.14 |
| G/A | 6 (9.8) | 10 (8.7) | |
| A/A | 2 (3.3) | 0 (0) | |
| C3402T (*17) | |||
| C/C | 60 (98.4) | 114 (99.1) | 0.64 |
| C/T | 1 (1.6) | 1 (0.9) | |
| T/T | 0 (0) | 0 (0) | |
|
| |||
| ABCB1 Genotype | |||
| C1236T | |||
| C/C | 5 (8.2) | 15 (13.0) | 0.53 |
| C/T | 30 (49.2) | 49 (42.6) | |
| T/T | 26 (42.6) | 51 (44.4) | |
| G2677T | |||
| G/G | 22 (36.1) | 26 (22.6) | 0.03* |
| G/T | 21 (34.4) | 63 (54.8) | |
| T/T | 18 (29.5) | 26 (22.6) | |
| C3435T | |||
| C/C | 30 (49.2) | 39 (33.9) | 0.02* |
| C/T | 20 (32.8) | 63 (54.8) | |
| T/T | 11 (18.0) | 13 (11.3) | |
aNo available data on genotype for two subjects (1 responder and 1 nonresponder) due to methodological problems.
*Statistical significance set at P < 0.05; comparisons were performed by the Chi-square test or Fisher's exact test as appropriate.