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A STOP sequence flanked by loxP sites was inserted between the Ubiquitin promoter and the mouse Ccl2 gene (a). The sequences of both the STOP cassette (bold) and the loxP sites (underlined) are shown later (b). The wild-type allele for Ccl2 gene is located in the region 11 C-E1 of chromosome 11 and the transgenic vector (bottom) is inserted in the ROSA26 locus of chromosome 6 (c). The procedure is designed to avoid chromosomal instabilities.
