Figure 4.

The effect of high-fat diet in body weight increase was evident in transgenic and wild-type mice ((a), (b)), but the different increase was immediate after dietary manipulation in transgenic. This effect was negligible in knockout mice (c). The combination of these effects with high-fat diet (d) shows similar results to facilitate comparison. These findings are not due to differences in the cumulative food intake ((e), (f)) indicating that CCL2 probably has no effect on appetite. *P < 0.05.