Figure 7.
RORγt−/− and WTCD4 T cells have comparable ability to induce GVHD. Lethally irradiated BALB/c mice were transplanted with TCD-BM alone or plus purified CD4+ T cells (1–2 × 106/mouse) isolated from WT or RORγt−/− mice on B6 background. Percentages of survival (A) and body weight change (B) are shown. Data cumulate 2 independent experiments with 8 to 9 mice per group.