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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: JACC Cardiovasc Imaging. 2013 Dec;6(12):10.1016/j.jcmg.2013.09.014. doi: 10.1016/j.jcmg.2013.09.014

Figure 4. Intravascular NIRF imaging of protease inflammation in experimental atherosclerosis.

Figure 4

(A, B) Fluoroscopic and angiographic images (A, yellow dotted lines: high magnification inset of the radiopaque tip of the catheter; B, solid yellow line: intravascular catheter tip position) positioned in the rabbit aorta, proximal to the iliac bifurcation. (C) Co-registered longitudinal IVUS demonstrates mild aortic plaques P1 and P2. (D) NIRF catheter pullback aligned with images A through C reveals NIRF protease activity at mild plaques (top) with 1-dimensional angle-averaged NIRF plot (bottom). (E) Superimposed longitudinal IVUS and NIRF fusion images (NIRF scale bar: yellow/white=strong, red/black=weak). (F, G) Longitudinal and (H, I) axial images of plaques P1 and P2. Reproduced with permission from (18).