Table 3. Elevated mtDNA levels and 28-d MICU mortality by group.
| Statistical Test | 28-d MICU Mortality | |||
| BWH RoCI(n = 200) | ME ARDS | |||
| All Patients(n = 243) | MICU Patientsa(n = 152) | Non-MICU Patientsb(n = 91) | ||
| Sensitivity | 80% | 75% | 81% | 67% |
| Specificity | 62% | 52% | 56% | 46% |
| Positive predictive value | 48% | 24% | 32% | 12% |
| Negative predictive value | 88% | 92% | 92% | 93% |
Elevated mtDNA level represents NADH dehydrogenase 1 DNA copy number of ≥3,200 copies/µl plasma.
a Includes MICU and cardiac ICU patients.
b Includes surgical ICU, trauma ICU, and neurological ICU patients.