. 2013 Dec 31;8(12):e83776. doi: 10.1371/journal.pone.0083776

Table 2. Top candidates of differentially expressed “autoimmune-specific” IFN signature genes in CD4⁺ T cells, CD16⁻ and CD16⁺ monocytes.

Affymetrix ID	Gene Symbol	SLE CD4⁺ T cells		SLE CD16⁻ monocytes		SLE CD16⁺ monocytes
		FC^a	P value^b	F^a	P value^b	F^a	P value^b
204533_at	CXCL10	5.5	2.37E-05	NS^c	NS	NS	NS
203603_s_at	ZEB2	4.8	4.41E-10	NS	NS	NS	NS
209498_at	CEACAM1	4.2	7.19E-07	NS	NS	NS	NS
206359_at	SOCS3	4.2	1.61E-06	4.7	1.50E-05	17.1	2.57E-09
204413_at	TRAF2	4.1	1.31E-07	NS	NS	NS	NS
205699_at	MAP2K6	−4.9	1.4E-11	NS	NS	NS	NS
235086_at	THBS1	NS	NS	14.7	9.83E-05	NS	NS
201110_s_at	THBS1	NS	NS	13.7	1.46E-04	26.3	NS
38037_at	HBEGF	NS	NS	11.8	2.55E-07	2.6	4.21E-05
208937_s_at	ID1	NS	NS	11.4	1.65E-11	NS	5.48E-03
202340_x_at	NR4A1	NS	NS	10.8	8.37E-10	2.3	NS
210397_at	DEFB1	NS	NS	10.7	4.77E-18	NS	1.08E-06
204420_at	FOSL1	NS	NS	10.3	6.28E-12	NS	NS
201109_s_at	THBS1	NS	NS	8.9	3.68E-04	NS	NS
205409_at	FOSL2	NS	NS	6.9	1.43E-13	NS	NS
205767_at	EREG	NS	NS	6.3	2.63E-05	NS	NS
203821_at	HBEGF	NS	NS	5.7	6.50E-07	2.5	NS
212285_s_at	AGRN	NS	NS	5.6	3.34E-07	NS	3.56E-03
208075_s_at	CCL7	NS	NS	5.3	1.05E-02	NS	NS
201005_at	CD9	NS	NS	4.7	1.02E-03	8.2	NS
224454_at	ETNK1	NS	NS	4.4	1.74E-14	NS	1.37E-03
218880_at	FOSL2	NS	NS	4.0	1.38E-14	3.9	NS
220088_at	C5AR1	NS	NS	3.9	8.81E-19	NS	NS
222566_at	SUV420H1	NS	NS	−4.1	8.01E-12	−3.6	6.75E-11
204798_at	MYB	NS	NS	−4.6	1.03E-04	NS	2.43E-08
230337_at	SOS1	NS	NS	−6.5	2.66E-05	−3.6	NS
209795_at	CD69	NS	NS	NS	NS	56.0	3.30E-16
210512_s_at	VEGFA	NS	NS	NS	NS	18.3	4.62E-08
200923_at	LGALS3BP	NS	NS	NS	NS	12.8	3.17E-08
227697_at	SOCS3	3.1	1.16E-06	3.7	1.35E-04	11.8	1.90E-15
210164_at	GZMB	2.0	2.12E-03	NS	NS	10.4	9.16E-08
219257_s_at	SPHK1	NS	NS	2.7	2.38E-12	9.0	1.49E-04
214617_at	PRF1	NS	NS	NS	NS	7.6	1.34E-07
220576_at	PGAP1	NS	NS	NS	NS	7.5	7.48E-05
206115_at	EGR3	NS	NS	NS	NS	6.3	3.74E-04
211828_s_at	TNIK	NS	NS	NS	NS	6.2	1.54E-03
205488_at	GZMA	NS	NS	NS	NS	6.0	1.40E-06
224516_s_at	CXXC5	NS	NS	NS	NS	4.7	1.57E-03
205863_at	S100A12	2.4	7.15E-02	NS	NS	4.7	1.74E-10
207655_s_at	BLNK	NS	NS	NS	NS	4.3	3.99E-04
213524_s_at	G0S2	NS	NS	NS	NS	4.2	1.29E-06
1569150_x_at	PDLIM7	NS	NS	2.3	3.63E-11	4.0	2.40E-06
202498_s_at	SLC2A3	NS	NS	2.1	6.17E-07	4.0	2.60E-07
228846_at	MXD1	NS	NS	NS	NS	4.0	6.23E-03
203618_at	FAIM2	NS	NS	NS	NS	−4.9	9.33E-07

This table summarizes top candidates of differentially expressed “autoimmune-specific” IFN signature genes in CD4⁺ T cells, CD16⁻ and CD16⁺ monocytes defined by a foldchange ≥4 or ≤−4.

^a FC: fold change.

^b P values was calculated by the comparison of SLE versus healthy donors before immunization. All values were Bonferroni-corrected for multiple-comparisons.

^c NS: Not significant with cutoff of FC > = 2 or < = −2 in SLE.

Table 2. Top candidates of differentially expressed “autoimmune-specific” IFN signature genes in CD4+ T cells, CD16− and CD16+ monocytes.

Table 2. Top candidates of differentially expressed “autoimmune-specific” IFN signature genes in CD4⁺ T cells, CD16⁻ and CD16⁺ monocytes.