TABLE 2.
Sequence similarities between chimpanzee Fab antibodies and their most related human germ line Ig genesa
| Chimpanzee Fab | VH homologue
|
VL homologue
|
||||
|---|---|---|---|---|---|---|
| Family (gene) | % Identity | Reference cited | Family (gene) | % Identity | Reference cited | |
| 5A7 | VH3 (COS-6) | 95 | 60 | Vκ3 (DPK-23) | 90 | 11 |
| 3C1 | VH1 (DP-10) | 88 | 60 | Vκ1 (L12a) | 92 | 32 |
| 3E4 | VH1 (DP-10) | 88 | 60 | Vκ2 (DPK-8) | 88 | 11 |
| 7G4 | VH3 (DP-54) | 92 | 60 | Vκ1 (L12a) | 95 | 32 |
| 5H2 | VH4 (DP-71) | 89 | 60 | Vκ1 (Va) | 94 | 48 |
| 5D9 | VH4 (DP-71) | 88 | 60 | Vκ1 (Va) | 93 | 48 |
a
The DNAPLOT program was used to search for the most homologous sequence of human IgG molecules in the database. The percent identity in the VH or VL region excluding CDR3 is indicated.