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. 2013 Dec 31;8(12):e84036. doi: 10.1371/journal.pone.0084036

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© 2013 Yamanaka et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Hematoxylin staining of coronal sections of 7-month-old aPKCλ flox/−; S1-cre (S1-cko) or flox/+ (Cont) female mice (left two panels), or 15-month-old aPKCλ flox/flox; C2-cre (C2-cko) or flox/+; C2-cre (Cont) male mice (right two panels). (B) Magnified images shown in (A). (C, D) Brain weight of 11-month-old aPKCλ flox/flox (Cont) or flox/flox; S1-cre (S1-cko) male mice (C), or 20-month-old aPKCλ flox/flox (Cont) or flox/flox; C2-cre (C2-cko) male mice (D). Numbers of mice (n) used for analysis are indicated. Values are means ± SD. Cor (cortex), Str (striatum), Hpc (hippocampus) and Th (thalamus). Bars are 5 mm (A) and 1 mm (B).