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. 2013 Dec 31;8(12):e84063. doi: 10.1371/journal.pone.0084063

Figure 6. RvD1 reduced renal interstitial fibrosis in the obstructed kidneys of wild type mice.

Figure 6

Mice underwent sham or unilateral ureteral obstruction (UUO) surgery. Two days after UUO surgery, mice received intraperitoneal injections of RvD1 for another two days and were killed on day 4. (A) Quantification of CD31+ peritubular capillary (PTC) lumina; (B) Western blotting analysis of kidney protein levels of NOS3, α-smooth muscle actin (α-SMA), fibronectin, collagen I and GAPDH. (C) Quantification of the relative abundance of NOS3, α-SMA, collagen I and GAPDH. Data are mean ±SD from groups of 6 mice and analysis by one-way ANOVA with post hoc analysis with Tukey's multiple comparison test. *p<0.05, **p<0.01, ***p<0.001.